My recent work has been at the National Institutes of Health (Bethesda, MD), where I was a postdoctoral fellow in Marius Clore's lab. I use advanced NMR (nuclear magnetic resonance) methods--particularly paramagnetic relaxation enhancement--to study protein structure and function. My main project has focused on calcium signaling, particularly how transient, invisible states of calmodulin contribute to its function. More recent work has explored protein aggregation in Huntington's disease. My work primarily employs NMR, but I also use various other biophysical techniques (fluorescence, EPR, ITC, DSC, CD), biochemical assays, and protein and DNA work.
I completed my doctorate at the University of Oxford in 2009, where I studied in the Department of Biochemistry in the laboratory of Iain Campbell (1941-2014). There, I used NMR, X-ray crystallography, and other methods to analyze protein-protein interactions in focal adhesions (particularly involving the integrins), with the ultimate goal of better understanding cell adhesion and migration.
Click here for some tools I developed for NMR and molecular biology research.
Click here to see my CV.
Click here to see a full up-to-date list of my publications.
Click here to read my graduate thesis.
Click here to read my undergraduate thesis.